XU Wei

Assistant Research Fellow

Research Areas

Natrual Products Chemistry

Drug ADMET

Education & Positions

University of Science and Technology of China (USTC), B.S., 1994

Massachusetts Institute of Technology, Ph.D., 2000

Nanjing University, Bachelor of Science, 1996-2000

Peking University, Research Assistant, 2000-2009

Peking University, Assistant Research Fellow, 2009-

Faculty Accolades

China Ministry of Education, Scientific Research Outstanding Achievement Award of Higher Education, Second Prize of Natural Science Award 2013

Research Interests

My research is focused on the ADMET of active natural products isolated from Traditional Chinese Medicines. Using diverse in vivo & in vitro models, including human intestinal bacteria, Caco-2, MDCK-pHaMDR, liver microsomes etc., the ADMET properties of some natural products have been elucidated in order to providing leading compounds with good PK properties.

Publications

1. Gui-Yun Cao, Xiu-Wei Yang, Wei Xu, Fei Li. New inhibitors of nitric oxide production from the seeds of Myristica fragrans. Food and Chemical Toxicology, 2013, 62:167-171.

2. Gui-Yun Cao, Wei Xu, Xiu-Wei Yang, Frank J. Gonzalez, Fei Li. New neolignans from the seeds of Myristica fragrans that inibit nitric oxide production. Food Chemistry, 2015, 173:231-237.

3. Wu Shuai, Xu Wei, Wang Fu-Rong, Yang Xiu-Wei*. Study of the biotransformation of Tongmai Formula by human intestinal flora and its intestinal permeability across the Caco-2 cell monolayer [J]. Molecules, 2015, 20(10):18704-18716.

4. Wu, Ni; Xu, Wei; Cao, Gui-Yun; Yang, Yan-Fang; Yang, Xin-Bao; Yang, Xiu-Wei*. The blood-brain barrier permeability of lignans and malabaricones from the seeds of Myristica fragrans in the MDCK-pHaMDR cell monolayer model. Molecules, 2016, 21(2): 134

5. Wei Wei, Xu Wei, Yang Xiu-Wei*. Two new phthalide dimers from the rhizomes of Ligusticum chuanxiong [J]. Journal of Asian Natural Products Research, 2017, 19(7): 704？711.