Department of Natural Medicines,School of pharmaceutical Sciences,Peking University

Wenhan Lin

Professor, Dr.

Research Areas

Marine Natural Product Chemistry

Education & Positions

University of Science and Technology of China (USTC), B.S., 1994

Massachusetts Institute of Technology, Ph.D., 2000

Shanghai Institute of Materia Medica, Chinese Academy of Sciences, MS and Ph.D, 1985-1990

School of Pharmaceutical Sciences, Peking University, postdoctoral fellow, 1990-1992

School of Pharmaceutical Sciences, Peking University, associate professor, 1992-1996

School of Pharmaceutical Sciences, Peking University, professor, 1996-present

Federal University of Rio de Janeiro (Brazil), visiting researcher, 1993-1994

Faculty of Pharmaceutical Sciences, Toho University (Japan), visiting researcher, 1995-1996

Duesseldorf University (Germany), visiting professor, 1999-2000

Faculty Accolades

Director of marine drug division of CPA 2015-present

Mercator-Fellow (Germany) 2017

Natural Science and TechnologyAward of CPA 2008

Chinese Young ChemistAward 2004

Research Interests

Our research interesting mainly focus on the bioactive metabolites derived from marine organisms (sponges and corals), marine mangrove plants and their associated microorganisms. The research work included the isolation, structure elucidation of novel natural products, bioassay of the obtained compounds, and structural modification of bioactive products for further new drug development, and the interreaction of drugs and target proteins. So far, we examined more than 50 species of marine organisms inhabited in South China Sea chemically, and more than 3500 natural products to be isolated, of which more than 400 new compounds are characterized. Part of them showed potent bioactivities including and HIV-1, anti-cancers, and other activities. Up to date,we published more than 200 papers in scientific journals, involving Org. Lett., Tetrahedron, JNP, EJMC, BMC, and Phytochemistry, more than 10 patients related to bioactive natural products were awarded.

Grants and fundings

National Natural Science Foundation of China (81630089, U1406402-1, 41376127, 30930109)

MOST-Hightech 973 Program (2015CB755906)

National Deep Sea Plan (DY135-B-05)

NSFC-TAMU (41411120224)

NSFC-DFG (GZ816)

(RMB>1,000,000)

Principal Investigator

Publications

1. S. Niu, L. Si, D. Liu, A. Zhou, Z. Zhang, Z. Shao, S. Wang, L. Zhang, D. Zhou, W. Lin*. Spiromastilactones: A new class of influenza virus inhibitors from deep-sea fungus. Euro. J. Med. Chem. 2016, 108, 229-244.

2. X. Chen, L. Si,D. Liu, P. Proksch, L. Zhang, D. Zhou,*W. Lin*. Neoechinulin B and its analoguesas potential entry inhibitors of influenza viruses, targeting viral hemagglutinin. Eur. J. Med. Chem. 2015, 93, 182-195.

3. H. Long,Z. Cheng,W. Huang,Q. Wu,X. Li,J. Cui,P. Proksch, W. Lin*. Diasteltoxins A？C, asteltoxin-based dimers from a mutant of the sponge-associated Emericella variecolor fungus. Org. Lett. 2016, 18, 4678？4681.

4. D. Liu, H. Lin, P. Proksch, X. Tang, Z. Shao,^, W. Lin* Microbacterins A and B, unusual peptaibols from the deep-sea actinomyceteMicrobacterium sediminis sp. nov. YLB-01(T). Org. Lett. 2015, 17 (5), 1220-1223.

5. A. Yang, L. Si, Z. Shi, L. Tian,D. Liu, D. Zhou,P. Proksch, W. Lin* “Nitrosporeusines A and B, unprecedented thioester-bearing alkaloids from the ArcticStreptomyces nitrosporeus” Org. Lett. 2013, 15, 5366-5369.

Faculty

Lin Wenhan