Dong Liu    Assistant Professor

Research Areas

Marine Natural Products

Fungal Bioactive Products

Education & Positions

University of Science and Technology of China (USTC), B.S., 1994

Massachusetts Institute of Technology, Ph.D., 2000

Shenyang Pharmaceutical University, Bachelor, 2001-2005

Shenyang Pharmaceutical University, Doctor, 2005-2009

The Institute of Medicinal Plant Development, Postdoctoral Fellow, 2009-2013

Peking University, Assistant Professor 2013-now

Faculty Accolades

Chinese Pharmaceutical Association Excellent Conference Report Second Price 2009

Research Interests

Our research focus on finding new bioactive secondary metabolites from marine organisms, especially form marine-derived fungi. We isolated fungal strains from sponge, soft coral, mangrove plants and deep-sea sediments. On one hand, bioassay-guided isolation would be carried out in our research. Fungi that exhibit anti-tumor, anti-bacterial, anti-inflammatory or lipid-lowering bioactivities will be selected out for further chemical investigation in order to find the bioactive compounds, and bioactive-structural relationships of the derivatives would be discussed to find new drug-lead compounds. On the other hand, our chemical investigation would be performed by means of chemical-guided isolation. The molecules with novel skeleton would be purified and their chemical structures would be identified including absolute configuration. The novel marine-derived secondary metabolites would be used as small molecular probes to discover newly potent drug targets.

Grants and fundings

National Natural Science Fundation of China (NSFC),21502004, RMB 240000, Principal Investigator

Beijing Natural Science Foundation (BNSF), 7182086, RMB 200000, Principal Investigator

Peking University-Fangzheng group Medical Innovation Research Fund, RMB 200000, Principal Investigator

Publications

1. Dong Liu^#, Yong Li, Xiaodan Li, Zhongbin Cheng, Jian Huang, Peter Proksch, Wenhan Lin*. Chartarolides A-C, novel meroterpenoids with antitumor activities. Tetrahedron Letters 2017, 58(19), 1826-1829.

2. Dong Liu^#, Hong Lin, Peter Proksh, Xixiang Tang, Zhongze Shao, Wenhan Lin*. Microbacterins A and B, new peptaibols from the deep sea actinomycete Microbacterium sediminis sp. nov. YLB-01(T). Organic Letters 2015, 17(5), 1220-1223.

3. Dong Liu^#, Aigang Yang, Chongming Wu, Peng Guo*, Peter Proksch, Wenhan Lin*. Lipid-lowering effects of farnesylquinone and related analogs from the marine-derived Streptomyces nitrosporeus. Bioorganic & Medicinal Chemistry Letters 2014, 24(22), 5288-5293.

4. Siwen Niu^#, Dong Liu^#, Xinxin Hu, Peter Proksch, Zhongzhe Shao*, Wenhan Lin*. Spiromastixones A-O, antibacterial chlorodepsidones from a deep sea-derived Spiromastix sp. fungus. Journal of Natural Products 2014, 77(1), 1021-1030.

5. Dong Liu^#, Jing Xu, Wei Jiang, Zhiwei Deng, Nicole J. de.Voogd, Peter Proksch. Xestospongienols A-L, brominated acetylenic acids form the Chinese Marine sponge Xestospongia testudinaria. Helvetica Chimica Acta 2011, 94, 1600-1607.