Donghui Yang

Associate Professor

Research Areas

Natural Product Biosynthesis

Education & Positions

University of Science and Technology of China (USTC), B.S., 1994

Beijing University of Chinese Medicine, Ph. D, 1995-1998

Peking University, Postdoctoral Fellow, 1998-2000

Peking University, Assistant Professor 2000-2003, Associate Professor 2003-

Faculty Accolades

First Prize of Science Technology of China Association of Chinese Medicine 2007

The Extraordinary teacher of Health Science Center of Peking University 2005, 2010, 2015

Research Interests

Our research mainly focuses on ①the discovery of novel natural products from endophytic bacteria of biological samples originated from marine or medicinal plants; ②synthetic biology of functional natural products. We construct the libraries of endophytic actinomycetes and genomic DNAs (3000 strains up to now). We carry out the screening of potential terpenoid-producing strains by using genome mining methods, and discover new terpenoids from these strains. The heterologous expression of whole diterpenoid biosynthetic gene cluster or individual terpenoid cyclase in heterologous hosts also be carried out.

Grants and fundings

1. General Program of National Natural Science Foundation of China (Grant No. 81573326), Discovery of ent-CPP derived diterpenoids from sponge endogenous actinomycetes and functional characterization of the diterpene synthases from their biosynthetic pathways, RMB 540,000, 2017.01-2019.12, Topic responsible person.

2. General Program of National Natural Science Foundation of China (Grant No. 21072012), Studies on functional enzymes with deglycosylation and demethylation activity, RMB 360,000, 2011.01-2013.12, Topic responsible person.

3. General Program of National Natural Science Foundation of China (Grant No. 30672622), Biological technology for obtaining enterodiol and enterolactone and their activity against menopausal depression, RMB 280,000, 2007.01-2009.12, Topic responsible person.

4. National High Technology Research and Development Program of China (Grant No. 2011ZX-09102-011-06), Preclinical study of new drug SECO against menopause syndrome, RMB 2020,000, 2011.01-2013.12, Topic responsible person.

Publications

1. Jing Jin, Xiaoyan Yang, Tan Liu, Hua Xiao, Guiyang Wang, Mengjie Zhou, Fawang Liu, Yingtao Zhang, Dong Liu, Minghua Chen, Wei Cheng, Donghui Yang*, and Ming Ma*. Fluostatins M-Q featuring a 6-5-6-6 ring skeleton and high oxidized A-rings from marine Streptomyces sp. PKU-MA00045. Marine Drugs 2018, 16, 87.

2. Mengjie Zhou, Fawang Liu, Xiaoyan Yang, Jing Jin, Xin Dong, Ke-Wu Zeng, Dong Liu, Yingtao Zhang, Ming Ma* and Donghui Yang*. Bacillibactin and Bacillomycin Analogues with Cytotoxicities against Human Cancer Cell Lines from Marine Bacillus sp. PKU-MA00093 and PKU-MA00092. Marine Drugs 2018, 16, 22.

3. Jia-Xing Chen, Chao-Yin Deng, Ying-Tao Zhang, Zhen-Ming Liu, Ping-Zhang Wang, Shu-Lin Liu, Wei Qian, Dong-Hui Yang*. Cloning, expression, and characterization of a four-component O-demethylase from human intestinal bacterium Eubacterium limosum ZL-II. Applied Microbiology and Biotechnology 2016, 21, 9111-9124.

4. Yi-Lun Tao, Dong-Hui Yang*, Ying Zhang, Zi-Qiang Wang, Yun-Shan Wang, Shao-Qing Cai, Shu-Lin Liu*. Cloning, expression, and characterization of the β-glucosidase hydrolyzing secoisolariciresinol diglucoside to secoisolariciresinol from Bacteroides uniformis ZL1. Applied Microbiology and Biotechnology 2014, 98, 2519-2531.

5. Hong-Yun Zhu, Miao-Xin Li, Dong-Hui Yang*, Yi-Lun Tao, Ying Zhang, Shu-Lin Liu*. Biotransformation of the SDG in defatted flaxseed into END co-cultured by three single bacterial colonies. Process Biochemistry 2014, 49: 19-24.