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程伟

副研究员

  

  

  

  程伟,博士,副研究员,硕士研究生导师,中国药学会海洋药物专业委员会委员

  电话:+86-10-82805746

  E-mail:chengwei@bjmu.edu.cn

  

  教育经历:

  2018/09-2020/09  美国加州大学洛杉矶分校,化学与生物工程系,访问学者,合作导师:Prof. Yi Tang

  2006/09-2009/06,中国医学科学院药物研究所,药物化学专业,博士,

  导师:石建功教授

  2003/09-2006/06,河北医科大学,药学院,药物化学专业,硕士,

  导师:张嫡群教授

  1999/09-2003/06,河北医科大学,药学院,学士

  

  工作经历:

  2009/08-至今,北京大学,药学院天然药物学系

  

  研究方向:海洋天然药物化学

  

  主持或参加科研项目情况:

  1.基于海洋天然产物抗污生态特征的抗细菌生物膜功能分子的发现

  (国家自然科学基金面上项目,2017/01-2020/12,项目负责人)

  2.海绵Leucetta chagosensis中特征性咪唑生物碱及其抗肿瘤活性研究

  (北京市自然科学基金面上项目,2017/01-2019/12,项目负责人)

  3. Iotrochota属海绵及其内生菌中含氮化合物及其抗肿瘤活性研究

  (国家自然科学基金青年基金,2014/01-2016/12,项目负责人)

  4. 苯骈噁嗪酮类衍生物的抗乙肝病毒生物活性及构效关系研究

  (教育部博士点基金,2011/01-2013/12,项目负责人)

  5. 环境胁迫海洋生物产生的新药源分子研究

  (国家自然科学基金重大项目,2020/01-2024/12,子课题负责人)

  6. 深海动植物来源候选药物系统成药性评价

  (科技部重点专项课题,2018/08-2021/12,子课题负责人)

  

  代表性研究论文:

  1.Yee, Danielle A.#; Kakule, Thomas B.#; Cheng, Wei #; Chen, Mengbin; Chong, Christine T. Y.; Hai, Yang; Hang, Leibniz F.; Hung, Yiu-Sun; Liu, Nicholas; Ohashi, Masao; Okorafor, Ikechukwu C.; Song, Yongxiang; Tang, Mancheng; Zhang, Zhuan; Tang, Yi *. Genome Mining of Alkaloidal Terpenoids from a Hybrid Terpene and Nonribosomal Peptide Biosynthetic Pathway. J. Am. Chem. Soc. , 2020, 142(2): 710-714.

  2.Jiru Wu, Xiaodan Li, Xingchen Guo, Zhongbin Cheng, Junjun Meng, Wei Cheng*, Wenhan Lin*. Briarane-type diterpenoids from a gorgonian coral Ellisella sp. With anti-HBV activities. Bioorganic chemistry (2020), 105, 104423.

  3.Xiaodan Li#, Hui Liu#, Wei Cheng#, Jie Wang, He Zhang, Fengmin Lu, Xiangmei Chen*, Wenhan Lin*. Junceellolide B, a novel inhibitor of Hepatitis B virus. Bioorganic & Medicinal Chemistry (2020), 28(16), 115603.

  4.Junjun Meng#, Wei Cheng#, Hajar Heydari, Bin Wang, Kui Zhu, Belma Konuklugil, Wenhan Lin*. Sorbicillinoid-based Metabolites from a Sponge-derived Fungus Trichoderma saturnisporum. Marine Drugs, 2018, 16, doi:10.3390/md16070226.

  5.Jingyuan Sun, JiruWu, Bang An, Nicole J. de Voogd, Wei Cheng*, Wenhan Lin*. Bromopyrrole Alkaloids with the Inhibitory Effects against the Biofilm Formation of Gram Negative Bacteria. Marine Drugs, 2018, 16, doi: 10.3390/md16010009.

  6.Bang An, Fuling Yin, Nicole J. de Voogd, Xiaoguang Chen, Wei Cheng*, and Wenhan Lin*. Chagosendines A – C, New Metal Complexes of Imidazole Alkaloids from the Calcareous Sponge Leucetta chagosensis. Chemistry & Biodiversity, 2018, 15, doi: 10.1002/cbdv.201700481.

  7.Wei Cheng, Ming Ji, Xiaodan Li, Jinwei Ren, Fuling Yin, Leen van Ofwegen, Siwang Yu, Xiaoguang Chen, Wenhan Lin*. Fragilolides A-Q, norditerpenoid and briarane diterpenoids from the gorgonian coral Junceella fragilis . Tetrahedron, 2017, 73: 2518-2528.

  8.Wei Cheng, Zhen Liu, Yang Yu, Leen van Ofwegen, Peter Proksch, Siwang Yu*, Wenhan Lin*. An unusual spinaceamine-bearing pregnane from a soft coral Scleronephthya sp. inhibits the migration of tumor cells. Bioorganic & Medicinal Chemistry Letters, 2017, 27: 2736-2741.

  9.Wei Cheng, Xiaodan Li, Fuling Yin, Leen van Ofwegen, and Wenhan Lin*. Halogenated Briarane Diterpenes with Acetyl Migration from the Gorgonian Coral Junceella fragilis . Chemistry & Biodiversity, 2017, 14, doi: 10.1002/cbdv.201700053

  10.Wei Cheng, Jinwei Ren, Qixi Huang, Hailin Long, Hongwei Jin, Liangren Zhang, Huagang Liu, Leen van Ofwegen, Wenhan Lin*. Pregnane steroids from a gorgonian coral Subergorgia suberosa with anti-flu virus effects. Steroids, 2016, 108: 99-104.

  11.Qixi Huang, Wei Cheng*, Hailin Long, Huagang Liu, Leen van Ofwegen, and Wenhan Lin*. Subergane-Type Sesquiterpenes from Gorgonian Coral Subergorgia suberosa with Antibacterial Activities. Helvetica Chimica Acta, 2015, 98: 1202-1209.

  12.Wei Cheng, Dong Liu, Fengying Zhang, Qingying Zhang, Patchara Pedpradab, Peter Proksch, Hong Liang, Wenhan Lin*. Formamidobisabolene-based derivatives from a sponge Axinyssa sp. Tetrahedron, 2014, 70: 3576-3583.