范爱丽 副研究员 硕士生导师
北京大学药学院天然药物学系
天然药物及仿生药物全国重点实验室
电子邮箱：fanaili@bjmu.edu.cn
地址：北京市海淀区学院路38号，邮编：100191
教育背景
2011. 9-2015. 7，博士，药学与生物技术，德国马尔堡大学
2009. 9-2011. 7，硕士，天然药物化学，北京大学
2005. 9-2009. 7，学士，药学，北京大学
工作经历
2020. 12-，副研究员，北京大学
2015. 9-2020. 11，副教授，北京化工大学
2015. 10-2017. 8，助理研究员，中国科学院微生物研究所
科研与教学服务
研究生必修课《天然药物前沿概论》授课教师
研究方向
1.基于生物合成和合成生物学的海洋天然产物发现
2.海洋天然产物生物合成途径解析及关键酶催化机制探究
3.基于异源表达/代谢调控的活性药源分子生物制造
研究项目
2025.11，国家自然科学基金面上项目，项目负责人
2022.11，科技部重点研发青年科学家项目，项目负责人
2022.01，国家自然科学基金面上项目，项目负责人
2019.07，科技部重点研发计划，子课题负责人
2019.01，国家自然科学基金青年基金项目，项目负责人
代表性论文
1. Sun, Z., Wu, M., Zhong, B., Wu, J., Liu, D., Ren, J., Fan, S., Lin, W., and Fan, A.(Fan, Aili)* (2024). Target discovery of dhilirane-type meroterpenoids by biosynthesis guidance and tailoring enzyme catalysis. J . Am . Chem . Soc . 10.1021/jacs.4c09298.
2. Wang, M., Wu, M., Han, M., Niu, X., Fan, A., Zhu, S., and Tong, Y. (2024). Mining the Biosynthetic Landscape of Lactic Acid Bacteria Unearths a New Family of RiPPs Assembled by a Novel Type of ThiF-like Adenylyltransferases. ACS Omega 9, 30891-30903.
3. Ma, K.; Liu, J.; Huang, Z.; Wu, M.; Liu, D.; Ren, J.; Fan, A.*; Lin, W.*( 2024). Three-dimensional structural alignment based discovery and molecular basis of AtoB, catalyzing linear tetracyclic formation. Chem. Sci. 2024, DOI: 10.1039/D1034SC05590J.
4. Lu, Y.; Li, Y.; Dou, M.; Liu, D.; Lin, W.*; Fan, A.*(2024). Discovery of a hybrid molecule with phytotoxic activity by genome mining, heterologous expression, and OSMAC strategy. J . Agric . Food Chem ., 72, 18520-18527.
5. Fan, A.#,*; Zhong, B.#; Liu, D.#; Lu, Y.#; Wu, M.; Jin, H.; Shi, X.-M.; Ren, J.; Zhang, B.; Su, X.-d.; Ma, M.; Li, S.-M.; and Lin, W.*. (2024). Biosynthesis of epipyrone A reveals a highly specific membrane-bound fungal C -glycosyltransferase for pyrone galactosylation. Org . Lett . ,26, 1160-1165.
6. Huang, Z.; Liu, D.; Chen, S.; Ren, J.; Gao, C.; Li, Z.; Fan, A.*; and Lin, W.* (2024). Brominated depsidones with antibacterial effects from a deep-sea-derived fungus S piromastix sp. Mar. Drugs , 22, 78.
7. Liu, J.; Guo, X.; Guo, X.; Zhong, B.; Wang, T.; Liu, D.; Jin, H.; Ren, J.; Liu, Z.; Gao, J.; Li, S. M.; Fan, A.*; Lin, W.* (2022) Concise biosynthesis of tropone-containing spiromaterpenes by a sesquiterpene cyclase and a multifunctional P450 from a deep-sea-derived Spiromastix sp. fungus. J N at Prod , 85, 2723？2730.
8. Guo, X.; Meng, Q.; Liu, J.; Wu, J.; Jia, H.; Liu, D.; Gu, Y.; Liu, J.; Huang, J.; Fan, A.*; Lin, W.* (2022) Sclerotiamides C–H, notoamides from a marine gorgonian-derived fungus with cytotoxic activities. J . N at . Prod . , 85,1067–1078.
9. Wu, M.; Wei, H.; Ma, K.; Cui, P.; Zhu, S.; Lai, D.; Ren, J.; Wang, W.;Fan, A.*; Lin, W.; Su, H.* (2021) ThpacC acts as a positive regulator of homodimericin A biosynthesis and antifungal activities of Trichoderma harzianum 3.9236. J . Agric . Food Chem . , 69, 12695-12704.
10. Liu, X.; Zhang, Y.; Sun, Q.; Liu, Z.; Zhao, Y.; Fan, A.*; Su, H.* (2021) Rapid colonization and biodegradation of untreated commercial polyethylene wrap by a new strain of Bacillus velezensis C5. J . Environ . Manage . , 301, 113848.
11. Guo, X., Meng, Q., Niu, S., Liu, J., Guo, X., Sun, Z., Liu, D., Gu, Y., Huang, J., Fan, A. *and Lin, W.* (2021). Epigenetic manipulation to trigger production of guaiane-type sesquiterpenes from a marine-derived Spiromastix sp. fungus with antineuroinflammatory effects. J. Nat . Prod . 84, 1993-2003.
12. Wei, H., Wu, M., Fan, A.*and Su, H.* (2021). Recombinant protein production in the filamentou fungus Trichoderma . Chinese J. Chem. Eng. , 30:74-81.
13. Yu, X., Wei, H., Liu, X., Liu, D., Fan, A.*and Su, H. (2020). Enhanced resistance of Trichoderma harzianum LZDX-32-08 to hygromycin B induced by sea salt. Biotechnol Lett. , 43(1):213-222.
14. Yang, K., Li, S.-M., Liu, X.* and Fan, A.*(2020). Reinvestigation of the substrate specificity of a reverse prenyltransferase NotF from Aspergillus sp. MF297-2. Arch Microbiol .202，1419-1424.
15. Wang, Y.,Fan, A., Cohen, R.D., Dal Poggetto, G., Huang, Z., Yang, H., Martin, G.E., Sherer, E.C., Reibarkh, M., and Wang, X. (2023). Unequivocal identification of two-bond heteronuclear correlations in natural products at nanomole scale by i-HMBC. Nat. Commun. 14, 1842.
16. Zheng, L., Wang, H.,Fan, A. and Li, S. M. (2020). Oxepinamide F biosynthesis involves enzymatic D-aminoacyl epimerization, 3H-oxepin formation, and hydroxylation induced double bond migration. Nat Commun 11(1): 4914.
17. Li, W.#, Fan, A.#, Wang, L., Zhang, P., Liu, Z., An, Z., Yin, W.-B. (2018) Asperphenamate biosynthesis reveals a novel two-module NRPS system to synthesize amino acid esters in fungi. Chem. Sci. 9, 2589-2594. (# contribute equally)
18. Fan, A.#, Mi, W.#, Liu, Z., Zeng, G., Zhang, P., Hu, Y., Fang, W., Yin, W.-B. (2017) Deletion of a histone acetyltransferase leads to the pleiotropic activation of natural products in Metarhizium robertsii . Org. Lett. 19,1686-1689.(# contribute equally)
