范爱丽 副研究员 硕士生导师
北京大学药学院天然药物学系
天然药物及仿生药物全国重点实验室
电子邮箱：fanaili@bjmu.edu.cn
地址：北京市海淀区学院路38号，邮编：100191
教育背景
2011. 9-2015. 8，博士，药学与生物技术，德国马尔堡大学
2005. 9-2011. 8，学士、硕士，药学（六年制），北京大学
工作经历
2020. 12-，副研究员，北京大学
2015. 9-2020. 11，副教授，北京化工大学
2015. 10-2017. 8，助理研究员，中国科学院微生物研究所
科研与教学服务
研究生必修课《天然药物前沿概论》授课教师
研究方向
1.基于生物合成和合成生物学的海洋天然产物发现
2.海洋天然产物生物合成途径解析及关键酶催化机制探究
3.基于异源表达/代谢调控的活性药源分子生物制造
研究项目
科技部重点研发青年科学家项目，项目负责人
国家自然科学基金面上项目，项目负责人
科技部重点研发计划，子课题负责人
国家自然科学基金青年基金项目，项目负责人
代表性论文：
1. Wu, M., Torrence, I., Liu, Y.-N., Wu, J., Ge, R., Ma, K., Liu, D., Ren, J., Fan, S., Ma, M., Siegel, J., Tantillo, D., Lin, W., and Fan, A.(Fan, Aili)* (2025). Characterization and engineering of a bisabolene synthase reveal unusual hydride shift and key residues critical for mono-, bi- and tricyclic sesquiterpenes formation. J. Am. Chem. Soc. , 147 (12) 10413-10422.
2. Sun, Z., Wu, M., Zhong, B., Wu, J., Liu, D., Ren, J., Fan, S., Lin, W., and Fan, A.* (2024). Target discovery of dhilirane-type meroterpenoids by biosynthesis guidance and tailoring enzyme catalysis. J . Am . Chem . Soc . 1 46 (44),30242-30251.
3. Wang, M., Wu, M., Han, M., Niu, X., Fan, A.*, Zhu, S.*, and Tong, Y.* (2024). Mining the Biosynthetic Landscape of Lactic Acid Bacteria Unearths a New Family of RiPPs Assembled by a Novel Type of ThiF-like Adenylyltransferases. ACS Omega 9, 30891-30903.
4. Ma, K.; Liu, J.; Huang, Z.; Wu, M.; Liu, D.; Ren, J.; Fan, A.*; Lin, W.*( 2024). Three-dimensional structural alignment based discovery and molecular basis of AtoB, catalyzing linear tetracyclic formation. Chem. Sci. 15 ,18490-18496.
5. Lu, Y.; Li, Y.; Dou, M.; Liu, D.; Lin, W.*; Fan, A.*(2024). Discovery of a hybrid molecule with phytotoxic activity by genome mining, heterologous expression, and OSMAC strategy. J . Agric . Food Chem ., 72, 18520-18527.
6. Fan, A.#,*; Zhong, B.#; Liu, D.#; Lu, Y.#; Wu, M.; Jin, H.; Shi, X.-M.; Ren, J.; Zhang, B.; Su, X.-d.; Ma, M.; Li, S.-M.; and Lin, W.*. (2024). Biosynthesis of epipyrone A reveals a highly specific membrane-bound fungal C -glycosyltransferase for pyrone galactosylation. Org . Lett . , 26 , 1160-1165.
7. Huang, Z.; Liu, D.; Chen, S.; Ren, J.; Gao, C.; Li, Z.; Fan, A.*; and Lin, W.* (2024). Brominated depsidones with antibacterial effects from a deep-sea-derived fungus S piromastix sp. Mar. Drugs , 22, 78.
8. Liu, J.; Guo, X.; Guo, X.; Zhong, B.; Wang, T.; Liu, D.; Jin, H.; Ren, J.; Liu, Z.; Gao, J.; Li, S. M.; Fan, A.*; Lin, W.* (2022) Concise biosynthesis of tropone-containing spiromaterpenes by a sesquiterpene cyclase and a multifunctional P450 from a deep-sea-derived Spiromastix sp. fungus. J . N at . Prod . , 85 , 2723？2730.
9. Guo, X.; Meng, Q.; Liu, J.; Wu, J.; Jia, H.; Liu, D.; Gu, Y.; Liu, J.; Huang, J.; Fan, A.*; Lin, W.* (2022) Sclerotiamides C–H, notoamides from a marine gorgonian-derived fungus with cytotoxic activities. J . N at . Prod . , 85 ,1067–1078.
10. Wu, M.; Wei, H.; Ma, K.; Cui, P.; Zhu, S.; Lai, D.; Ren, J.; Wang, W.;Fan, A.*; Lin, W.; Su, H.* (2021) ThpacC acts as a positive regulator of homodimericin A biosynthesis and antifungal activities of Trichoderma harzianum 3.9236. J . Agric . Food Chem . , 69 , 12695-12704.
