E-mail: ydhui@bjmu.edu.cn

　　教育和工作经历：

　　1998年毕业于北京中医药大学获医学博士学位，1998-2000年于北京大学药学院做博士后研究。2000年9月至今就职于北京大学药学院天然药物学系，期间曾先后在日本Eisai公司筑波薬物研究所（2001-2002）、日本长崎国际大学药学部（2008）和美国斯克里普斯研究所（The Scripps Research Institute, 2013-2014）访问交流。

研究工作及成果：

　　从事天然产物的发现、生物合成与生物转化研究。代表性研究工作包括：基于萜类合酶生物合成了一系列萜类活性分子骨架结构；建立了人肠道菌生物转化获得活性物质的技术路线，并对关键酶的功能进行了挖掘和表征。作为负责人承担了科技部重大新药创制专项、国家自然科学基金等科研项目20余项，研究成果在Angew. Chem. Int. Ed.、J. Am. Chem. Soc.、Commun. Chem.、ACS Catal.、Org. Lett.、J. Nat. Prod.等期刊发表论文40 余篇，授权专利5项。

代表性研究论文 (截止到2023年) ：

　　1. Tingting Lou, Annan Li, Houchao Xu, Jingfeng Pan, Baiying Xing, Ruibo Wu,* Jeroen S. Dickschat,* Donghui Yang,* and Ming Ma*. Structural Insights into Three Sesquiterpene Synthases for theBiosynthesis of Tricyclic Sesquiterpenes and Chemical SpaceExpansion by Structure-Based Mutagenesis. J. Am. Chem. Soc. 2023, 145, 8474-8485.

　　2. Baiying Xing, Houchao Xu, Annan Li, Tingting Lou, Meng Xu, Kaibiao Wang, Zhengren Xu, Jeroen S. Dickschat,* Donghui Yang,* and Ming Ma*.Crystal Structure Based Mutagenesis of Cattleyene Synthase Leads to the Generation of Rearranged Polycyclic Diterpenes. Angew. Chem. Int. Ed. 2022, 61, e202209785.

　　3. Baiying Xing, Jiahui Yu, Changbiao Chi, Xueyang Ma, Qingxia Xu, Annan Li, Yuanjie Ge, Zhengdong Wang, Tan Liu, Hongli Jia, Fuling Yin, Juan Guo, Luqi Huang, Donghui Yang* and Ming Ma*. Functional characterization and structural bases of two class I diterpene synthases in pimarane-type diterpene biosynthesis. Commun. Chem. 2021, 4, 140.

　　4. Jiahui Yu, Juan Song, Changbiao Chi, Tan Liu, Tongtong Geng, Zonghui Cai, Weidong Dong, Cheng Shi, Xueyang Ma, Zhongyi Zhang, Xiaojie Ma, Baiying Xing, Hongwei Jin, Liangren Zhang, Suwei Dong, Donghui Yang, and Ming Ma*. Functional characterization and crystal structure of the bifunctional thioesterase catalyzing epimerization and cyclization in skyllamycin biosynthesis. ACS Catal. 2021, 11, 11733-11741.

　　5. Tan Liu, Xiaojie Ma, Jiahui Yu, Wensheng Yang, guiyang wang, Zhengdong Wang,Yuanjie Ge, Juan Song, Hua Han, Wen Zhang, Donghui Yang, Xuehui Liu* and Ming Ma*. Rational generation of lasso peptides based on biosynthetic gene mutations and site-selective chemical modifications. Chem. Sci. 2021, 12, 12353-12364.

　　6. Hua Xiao, Guiyang Wang, ZhengdongWang, Yi Kuang, Juan Song, Jing Jin, Min Ye, Donghui Yang*, Ming Ma*. Generation of Unusual Aromatic Polyketides by Incorporation of Phenylamine Analogues into a C-Ring-Cleaved Angucyclinone. Molecules 2021, 26, 1959.

　　7. Yuanjie Ge, Guiyang Wang, Jing Jin, Tan Liu, Xueyang Ma, Zhongyi Zhang, Tongtong Geng, Juan Song, Xiaojie Ma, Yingtao Zhang, Donghui Yang*, Ming Ma*. Discovery and Biosyntheses of Pepticinnamins G-M Featuring Three Enzyme-Catalyzed Nonproteinogenic Amino Acid Formation. J. Org. Chem . 2020, 85, 8673-8682.

　　8. Xiaoxu Sun, Guiyang Wang, Hua Xiao, Jingyi Jiang, Dongliang Xiao, Baiying Xing, Annan Li, Yingtao Zhang, Kai Sun, Yuquan Xu, Lanping Guo, Donghui Yang*, Ming Ma*. Strepimidazoles A？G from the Plant Endophytic Streptomyces sp. PKU-EA00015 with Inhibitory Activities against a Plant Pathogenic Fungus. J. Nat. Prod . 2020, 83, 2246-2254.

　　9. Tan Liu, Jing Jin, Xiaoyan Yang, Juan Song, Jiahui Yu, Tongtong Geng, Zhongyi Zhang, Xueyang Ma, Guiyang Wang, Hua Xiao, Yuanjie Ge, Xiaoxu Sun, Baiying Xing, Xiaojie Ma, Changbiao Chi, Yi Kuang, Min Ye, Hailong Wang, Youming Zhang, Donghui Yang*, and Ming Ma*. Discovery of a Phenylamine-Incorporated Angucyclinone from Marine Streptomyces sp. PKU-MA00218 and Generation of Derivatives with Phenylamine Analogues. Org. Lett. 2019, 21, 2813-2817.

　　10. Jing Jin, Xiaoyan Yang, Tan Liu, Hua Xiao, Guiyang Wang, Mengjie Zhou, Fawang Liu, Yingtao Zhang, Dong Liu, Minghua Chen, Wei Cheng, Donghui Yang*, and Ming Ma*. Fluostatins M-Q featuring a 6-5-6-6 ring skeleton and high oxidized A-rings from marine Streptomyces sp. PKU-MA00045. Marine Drugs 2018, 16, 87. doi: 10.3390/md16030087.

　　11. Mengjie Zhou, Fawang Liu, Xiaoyan Yang, Jing Jin, Xin Dong, Ke-Wu Zeng, Dong Liu, Yingtao Zhang, Ming Ma* and Donghui Yang*. Bacillibactin and Bacillomycin Analogues with Cytotoxicities against Human Cancer Cell Lines from Marine Bacillus sp. PKU-MA00093 and PKU-MA00092. Marine Drugs 2018, 16, 22. doi: 10.3390/md16010022.

　　12. Jia-Xing Chen, Chao-Yin Deng, Ying-Tao Zhang, Zhen-Ming Liu, Ping-Zhang Wang, Shu-Lin Liu, Wei Qian*, Donghui Yang*. Cloning, expression, and characterization of a four-component O -demethylase from human intestinal bacterium Eubacterium limosum ZL-II. Appl. Microbiol. Biot. 2016, 21, 9111-9124.