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乔雪

副教授,博士生导师

  

  

     乔雪,副教授,博士生导师。

  办公电话:010-82801516

  电子邮箱:qiaoxue@bjmu.edu.cn

  课题组主页 http://sklnbd.bjmu.edu.cn/k/e/action/ListInfo/?classid=41

  

个人简历

  1985年7月出生于北京

  2009/09–2012/07,北京大学,药学院天然药物学系,博士。

  2003/09–2009/07,北京大学,药学院(六年制),学士、硕士。

  2012/08-2018/07,北京大学,药学院天然药物学系,讲师。

  2016/10-2018/04,英国John Innes Centre,访问学者/博士后。

  2018/08-现在,北京大学,药学院天然药物学系,副教授。

  

研究领域

  1. 中药药效成分生物合成机制。

  2. 中药化学成分及体内代谢分析新方法。

  

科研项目

  1. 国家自然科学基金面上项目,81973448,2020/01-2023/12,主持。

  2. 北京市自然科学基金杰出青年科学基金,JQ18027,2018/11-2021/12,主持。

  3. 国家重点研发计划,2018YFC1707904,2018/12-2021/12,课题负责人。

  4. 北大医学青年科技创新培育基金,BMU2018PY009,2019/01-2019/12,主持。

  5. 中国科协青年人才托举工程,YESS20160044,2016/01-2018/12,主持。

  6. 国家自然科学基金青年项目,81303294,2014/01-2016/12,主持。

  

奖励与学术职务

  2019年中药分析与标准青年科学家奖(世界中联中药分析专业委员会)。

  Fitoterapia杂志副主编(2019.9-)

  WJTCM杂志青年编委(2018.8-)

  

代表论文

  1. Kuan Chen, Zhimin Hu, Wei Song, Zi-long Wang, Jun-bin He, Xiao-meng Shi, Qing-hua Cui, Xue Qiao*, Min Ye*. Diversity of O -glycosyltransferases contributes to the biosynthesis of flavonoid and triterpenoid glycosides in Glycyrrhiza uralensis . ACS Synth. Biol. 2019, DOI: 10.1021/acssynbio.9b00171.

  2. Jun-Bin He#, Peng Zhao#, Zhi-Min Hu, Shuang Liu, Yi Kuang, Meng Zhang, Bin Li, Cai-Hong Yun*, Xue Qiao*, Min Ye*. Molecular characterization and structural basis of a promiscuous C -glycosyltransferase from Trollius chinensis . Angew. Chem. Int. Ed. 2019, 58 , 11513-11520.

  3. Lu-lu Xu, Zhan-peng Shang, Tao Bo, Long Sun, Qi-lei Guo, Xue Qiao*, Min Ye*. Rapid quantitation and identification of the chemical constituents in Danhong Injection by liquid chromatography coupled with orbitrap mass spectrometry. J. Chromatogr. A 2019, doi: 10.1016/j.chroma.2019.460378.

  4. Zilong Wang#, Shuang Wang#, Zheng Xu#, Mingwei Li, Kuan Chen, Yaqun Zhang, Zhimin Hu, Meng Zhang, Zhiyong Zhang*, Xue Qiao*, Min Ye*.Highly promiscuous flavonoid 3- O -glycosyltransferase from Scutellaria baicalensis . Org. Lett. 2019, 21 , 2241?2245.

  5.Junbin He#, Kuan Chen#, Zhi-min Hu, Kai Li, Wei Song, Li-yan Yu, Chung-Hang Leung, Dik-Lung Ma, Xue Qiao*, Min Ye*. UGT73F17, a new glycosyltransferase from Glycyrrhiza uralensis , catalyzes the regiospecific glycosylation of pentacyclic triterpenoids. Chem. Commun. 2018 , 54(62), 8594-8597.

  6. Xue Qiao#, Qi Wang#, Shuang Wang, Yi Kuang, Kai Li, Wei Song, Min Ye*. A 42-markers pharmacokinetic study reveals interactions of berberine and glycyrrhizic acid in the anti-diabetic Chinese medicine formula Gegen-Qinlian Decoction. Front. Pharmacol. 2018, 9, 622.

  7. Wei Song#, Xue Qiao#, Kuan Chen, Ying Wang, Shuai Ji, Jin Feng, Kai Li, Yan Lin, Min Ye*. Biosynthesis-based quantitative analysis of 151 secondary metabolites of licorice to differentiate medicinal Glycyrrhiza species and their hybrids. Anal. Chem. 2017 , 89(5), 3146-3153.

  8. Xue Qiao, Xiong-hao Lin, Shuai Ji, Zheng-xiang Zhang, Tao Bo, De-an Guo, Min Ye*. Global profiling and novel structure discovery using multiple neutral loss/precursor ion scanning combined with substructure recognition and statistical analysis (MNPSS): Characterization of terpene-conjugated curcuminoids in Curcuma longa as a case study. Anal. Chem. 2016 , 88(1), 703-710.

  9. Xue Qiao#, Qi Wang#, Wei Song, Yi Qian, Yao Xiao, Rong An, De-an Guo, Min Ye*. A chemical profiling solution for Chinese medicine formulas using comprehensive and loop-based multiple heart-cutting two-dimensional liquid chromatography coupled withquadrupole time-of-flight mass spectrometry. J. Chromatogr. A 2016 , 1438, 198-204.

  10. Xue Qiao#, Ru Li#, Wei Song, Wen-juan Miao, Jia Liu, Hu-biao Chen, De-an Guo, Min Ye*. A targeted strategy to analyze untargeted mass spectral data: rapid chemical profiling of Scutellaria baicalensis using ultra-high performance liquid chromatography coupled with hybrid quadrupole orbitrap mass spectrometry and key ion filtering. J. Chromatogr. A 2016, 1441 , 83-95.