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徐正仁

助理教授,博士生导师

徐正仁 助理教授,博士生导师

 地址:北京市海淀区学院路38号

邮编:100191

电话:010-82805253

E-mail:zhengrenxu@bjmu.edu.cn

 

研究兴趣

1. 天然产物的化学-酶法合成

2. 新型酶催化反应研究

3. 天然产物药物化学研究 

 

教育背景

2001年-2005年,学士,药学,北京大学药学院

2005年-2007年,硕士,生药学,北京大学药学院(导师:屠鹏飞教授)

2007年-2011年,博士,化学生物学,北京大学药学院(导师:贾彦兴教授,张礼和教授)

 

工作经历

2011年10月-2014年9月,博士后,瑞士洛桑联邦理工大学(导师:祝介平教授)

2014年10月-2018年3月,博士后,美国斯克利普斯研究所(导师:沈奔教授)

2018年4月至今,助理教授,北京大学药学院天然药物学系

 

代表性论文

1. Zheng, X.; Li, Y.; Guan, M.; Wang, L.; Wei, S.; Li, Y.-C.; Chang, C.-Y.; Xu, Z.* Biomimetic total synthesis of the spiroindimicin family of natural products. Angew. Chem. Int. Ed. 2022, 61(38), e202208802. (contribute equally)

2. Hsu, S.-H.; Zhang, S.; Huang, S.-C.; Wu, T.-K.; Xu, Z.*; Chang, C.-Y.* Characterization of enzymes catalyzing the formation of the nonproteinogenic amino acid L-Dap in capreomycin biosynthesis. Biochemistry 2021, 60, 77-84.

3. Gao, Z.; Wang, Y.; Song, H.; Xu, Z.*; Jia, Y.* Cascade cyclization reaction initiated by benzylic carbocation of indole: scope and mechanistic insights. Chin. J. Org. Chem. 2021, 41, 3126-3133. (高中润,王媛,宋航,徐正仁*,贾彦兴*;吲哚苄位碳正离子引发的串联环化反应的普适性和机理研究;有机化学2021413126-3133)

4. Xu, Z.; Fang, S.-M.; Bakowski, M. A.; Rateb, M. E.; Yang, D.; Zhu, X.; Huang, Y.; Zhao, L.-X.; Jiang, Y.; Duan, Y.; Hull, M. V.; McNamara, C. W.; Shen, B.* Discovery of kirromycins with anti-Wolbachia activity from Streptomyces sp. CB00686. ACS Chem. Biol. 2019, 14, 1174-1182.(contribute equally)

5. Xu, Z.; Pan, G.; Zhou, H.; Shen, B.* Discovery and characterization of 1-aminocyclopropane-1-carboxylic acid synthase of bacterial origin. J. Am. Chem. Soc. 2018, 140, 16957-16961.(contribute equally)

6. Xu, Z.*; Wang, Q.; Zhu, J.* Metamorphosis of cycloalkenes for the divergent total synthesis of polycyclic indole alkaloids. Chem. Soc. Rev. 2018, 47, 7882-7898.

7. Pan, G.; Xu, Z.; Guo, Z.; Hindra; Ma, M.; Yang, D.; Zhou, H.; Gansemans, Y.; Zhu, X.; Huang, Y.; Zhao, L.-X.; Jiang, Y.; Cheng, J.; Nieuwerburgh, F. V.; Suh, J.-W.; Duan, Y.; Shen, B.* Discovery of the leinamycin family of natural products by mining actinobacterial genomes. Proc. Natl. Acad. Sci. USA 2017, 114, E11131-E11140.(contribute equally)

8. Zhang, B.; Xu, Z.; Teng, Q.; Pan, G.; Ma, M.; Shen, B.* A long-range acting dehydratase domain as the missing link for C17-dehydration in iso-migrastatin biosynthesis. Angew. Chem. Int. Ed. 2017, 56, 7247-7251.(contribute equally)

9. Xu, Z.; Bao, X.; Wang, Q.; Zhu, J.* An enantioselective total synthesis of (-)-isoschizogamine. Angew. Chem. Int. Ed. 2015, 54, 14937-14940. (Highlighted: in Synfacts 2016, 12, 5.) (contribute equally)

10. Tong, S.; Xu, Z.; Mamboury, M.; Wang, Q.; Zhu, J.* Aqueous titanium trichloride-promoted reductive cyclization of o-nitrostyrenes to indoles: development and application to the synthesis of rizatriptan and aspidospermidine. Angew. Chem. Int. Ed. 2015, 54, 11809-11812. (contribute equally)

11. Xu, Z.; Wang, Q.; Zhu, J.* Total syntheses of (-)-mersicarpine, (-)-scholarisine G, (+)-melodinine E, (-)-leuconoxine, (-)-leuconolam, (-)-leuconodine A, (+)-leuconodine F, and (-)-leuconodine C: self-induced diastereomeric anisochronism (SIDA) phenomenon for scholarisine G and leuconodine A and C. J. Am. Chem. Soc. 2015, 137, 6712-6724.

12. Xu, Z.; Wang, Q.; Zhu, J.* Enantioselective total syntheses of leuconolam-leuconoxine- mersicarpine group monoterpene indole alkaloids. J. Am. Chem. Soc. 2013, 135, 19127-19130. (Highlighted: in Synfacts 2014, 10, 232.)

13. Xu, Z.; Wang, Q.; Zhu, J.* Palladium-catalyzed decarboxylative vinylation of potassium nitrophenyl acetate: application to the total synthesis of (±)-goniomitine. Angew. Chem. Int. Ed. 2013, 52, 3272-3276. (Highlighted: in Synfacts 2013, 9, 461.; in Organic Chemistry Portal, http://www.organic-chemistry.org/Highlights/2013/25November.shtmand http://www.organic-chemistry.org/Highlights/2014/10March.shtm.)

14. Xu, Z.; Zhang, F.; Zhang, L.; Jia, Y.* Total synthesis of (-)-indolactam V. Org. Biomol. Chem. 2011, 9, 2512-2517.

15. Xu, Z.; Hu, W.; Liu, Q.; Zhang, L.; Jia, Y.* Total synthesis of clavicipitic acid and aurantioclavine: stereochemistry of clavicipitic acid revisitied. J. Org. Chem. 2010, 75, 7626-7635.

16. Xu, Z.; Li, Q.; Zhang, L.; Jia, Y.* Efficient total synthesis of (-)-cis-clavicipitic acid. J. Org. Chem. 2009, 74, 6859-6862. (With a correction: J. Org. Chem. 2010, 75, 6316; Highlighted in Organic Chemistry Portal, http://www.organic-chemistry.org/Highlights/2010/21June.shtm.)

17. Xu, Z.; Hu, W.; Zhang, F.; Li, Q.; Lü, Z.; Zhang, L.; Jia, Y.* Palladium-catalyzed indole and azaindole synthesis by direct annulation of electron-poor o-chloroanilines and o-chloroaminopyridines with aldehydes.Synthesis 2008, 3981-3987.

18. Xu, Z.-R.; Chai, X.-Y.; Bai, C.-C.; Ren, H.-Y.; Lu, Y.-N.; Shi, H.-M.; Tu, P.-F.* Xylocosides A-G, phenolic glucosides from the stems of Xylosma controversum. Helv. Chim. Acta2008, 91, 1346-1354.

19. Xu, Z.-R.; Lu, Y.-N.; Chai, X.-Y.; Ren, H.-Y.; Tu, P.-F.* Chemical constituents from Xylosma controversum. J. Chin. Pharm. Sci. 2007, 16, 218-222.