徐正仁 助理教授，博士生导师
地址：北京市海淀区学院路38号
邮编：100191
电话：010-82805253
E-mail：zhengrenxu@bjmu.edu.cn
研究兴趣
1. 天然产物的化学-酶法合成
2. 新型酶催化反应研究
3. 天然产物药物化学研究
教育背景
2001年-2005年，学士，药学，北京大学药学院
2005年-2007年，硕士，生药学，北京大学药学院（导师：屠鹏飞教授）
2007年-2011年，博士，化学生物学，北京大学药学院（导师：贾彦兴教授，张礼和教授）
工作经历
2011年10月-2014年9月，博士后，瑞士洛桑联邦理工大学（导师：祝介平教授）
2014年10月-2018年3月，博士后，美国斯克利普斯研究所（导师：沈奔教授）
2018年4月至今，助理教授，北京大学药学院天然药物学系
代表性论文
1. Zheng, X.？; Li, Y.？; Guan, M.; Wang, L.; Wei, S.; Li, Y.-C.; Chang, C.-Y.; Xu, Z.* Biomimetic total synthesis of the spiroindimicin family of natural products. Angew. Chem. Int. Ed. 2022, 61(38), e202208802. (？contribute equally)
2. Hsu, S.-H.; Zhang, S.; Huang, S.-C.; Wu, T.-K.; Xu, Z.*; Chang, C.-Y.* Characterization of enzymes catalyzing the formation of the nonproteinogenic amino acid L-Dap in capreomycin biosynthesis. Biochemistry 2021, 60, 77-84.
3. Gao, Z.; Wang, Y.; Song, H.; Xu, Z.*; Jia, Y.* Cascade cyclization reaction initiated by benzylic carbocation of indole: scope and mechanistic insights. Chin. J. Org. Chem. 2021, 41, 3126-3133. (高中润，王媛，宋航，徐正仁*，贾彦兴*；吲哚苄位碳正离子引发的串联环化反应的普适性和机理研究；有机化学，2021，41，3126-3133)
4. Xu, Z.？; Fang, S.-M.？; Bakowski, M. A.？; Rateb, M. E.; Yang, D.; Zhu, X.; Huang, Y.; Zhao, L.-X.; Jiang, Y.; Duan, Y.; Hull, M. V.; McNamara, C. W.; Shen, B.* Discovery of kirromycins with anti-Wolbachia activity from Streptomyces sp. CB00686. ACS Chem. Biol. 2019, 14, 1174-1182.(？contribute equally)
5. Xu, Z.？; Pan, G.？; Zhou, H.; Shen, B.* Discovery and characterization of 1-aminocyclopropane-1-carboxylic acid synthase of bacterial origin. J. Am. Chem. Soc. 2018, 140, 16957-16961.(？contribute equally)
6. Xu, Z.*; Wang, Q.; Zhu, J.* Metamorphosis of cycloalkenes for the divergent total synthesis of polycyclic indole alkaloids. Chem. Soc. Rev. 2018, 47, 7882-7898.
7. Pan, G.？; Xu, Z.？; Guo, Z.; Hindra; Ma, M.; Yang, D.; Zhou, H.; Gansemans, Y.; Zhu, X.; Huang, Y.; Zhao, L.-X.; Jiang, Y.; Cheng, J.; Nieuwerburgh, F. V.; Suh, J.-W.; Duan, Y.; Shen, B.* Discovery of the leinamycin family of natural products by mining actinobacterial genomes. Proc. Natl. Acad. Sci. USA 2017, 114, E11131-E11140.(？contribute equally)
8. Zhang, B.？; Xu, Z.？; Teng, Q.？; Pan, G.; Ma, M.; Shen, B.* A long-range acting dehydratase domain as the missing link for C17-dehydration in iso-migrastatin biosynthesis. Angew. Chem. Int. Ed. 2017, 56, 7247-7251.(？contribute equally)
9. Xu, Z.？; Bao, X.？; Wang, Q.; Zhu, J.* An enantioselective total synthesis of (-)-isoschizogamine. Angew. Chem. Int. Ed. 2015, 54, 14937-14940. (Highlighted: in Synfacts 2016, 12, 5.) (？contribute equally)
10. Tong, S.？; Xu, Z.？; Mamboury, M.; Wang, Q.; Zhu, J.* Aqueous titanium trichloride-promoted reductive cyclization of o-nitrostyrenes to indoles: development and application to the synthesis of rizatriptan and aspidospermidine. Angew. Chem. Int. Ed. 2015, 54, 11809-11812. (？contribute equally)
11. Xu, Z.; Wang, Q.; Zhu, J.* Total syntheses of (-)-mersicarpine, (-)-scholarisine G, (+)-melodinine E, (-)-leuconoxine, (-)-leuconolam, (-)-leuconodine A, (+)-leuconodine F, and (-)-leuconodine C: self-induced diastereomeric anisochronism (SIDA) phenomenon for scholarisine G and leuconodine A and C. J. Am. Chem. Soc. 2015, 137, 6712-6724.
12. Xu, Z.; Wang, Q.; Zhu, J.* Enantioselective total syntheses of leuconolam-leuconoxine- mersicarpine group monoterpene indole alkaloids. J. Am. Chem. Soc. 2013, 135, 19127-19130. (Highlighted: in Synfacts 2014, 10, 232.)
13. Xu, Z.; Wang, Q.; Zhu, J.* Palladium-catalyzed decarboxylative vinylation of potassium nitrophenyl acetate: application to the total synthesis of (±)-goniomitine. Angew. Chem. Int. Ed. 2013, 52, 3272-3276. (Highlighted: in Synfacts 2013, 9, 461.; in Organic Chemistry Portal, http://www.organic-chemistry.org/Highlights/2013/25November.shtmand http://www.organic-chemistry.org/Highlights/2014/10March.shtm.)
14. Xu, Z.; Zhang, F.; Zhang, L.; Jia, Y.* Total synthesis of (-)-indolactam V. Org. Biomol. Chem. 2011, 9, 2512-2517.
15. Xu, Z.; Hu, W.; Liu, Q.; Zhang, L.; Jia, Y.* Total synthesis of clavicipitic acid and aurantioclavine: stereochemistry of clavicipitic acid revisitied. J. Org. Chem. 2010, 75, 7626-7635.
16. Xu, Z.; Li, Q.; Zhang, L.; Jia, Y.* Efficient total synthesis of (-)-cis-clavicipitic acid. J. Org. Chem. 2009, 74, 6859-6862. (With a correction: J. Org. Chem. 2010, 75, 6316; Highlighted in Organic Chemistry Portal, http://www.organic-chemistry.org/Highlights/2010/21June.shtm.)
17. Xu, Z.; Hu, W.; Zhang, F.; Li, Q.; Lü, Z.; Zhang, L.; Jia, Y.* Palladium-catalyzed indole and azaindole synthesis by direct annulation of electron-poor o-chloroanilines and o-chloroaminopyridines with aldehydes.Synthesis 2008, 3981-3987.
18. Xu, Z.-R.; Chai, X.-Y.; Bai, C.-C.; Ren, H.-Y.; Lu, Y.-N.; Shi, H.-M.; Tu, P.-F.* Xylocosides A-G, phenolic glucosides from the stems of Xylosma controversum. Helv. Chim. Acta2008, 91, 1346-1354.
19. Xu, Z.-R.; Lu, Y.-N.; Chai, X.-Y.; Ren, H.-Y.; Tu, P.-F.* Chemical constituents from Xylosma controversum. J. Chin. Pharm. Sci. 2007, 16, 218-222.
