Dr. Shizhong Chen

Shizhong Chen, Ph.D

Associate Professor of Pharmacognosy

Tel./fax: 010-82802723

Email: chenshizhong@sina.com.cn

EDUCATION & PROFESSIONAL EXPERIENCE

1982.7   B.Sc.  Shanxi University of Traditional Chinese Medicine

1994.7   Ph.D  China Pharmaceutical University

1993.1～1994.8  Toyama Medic

al and Pharmaceutical Universty

1994.9～1996.8  Postdoctoral Fellow

School of Pharmaceutical Sciences, Peking University

1997           Associate research fellow, Tutor for Postgraduates

School of Pharmaceutical Sciences, Peking University

RESEARCH INTERESTS

1.       New pharmaceutical preparations of Traditional Chinese Medicine and Pharmacognosy.

2.       The analysis and activity of natural medicines.

3.       The effective composition in Chinese Herbal Compound Formula.

research programs and achievements

Professor Chen has been engaged in scientific research on Traditional Chinese Medicine and Natural Medicines for nearly 30 years, and he is the editorial board member of Chinese Journal of Pharmaceutical Technology Economics and Management. At the same time, He has undertaken a few national projects as follows:

1.       National “Significant New Drug” monographic study “anti-cerebral ischemia new drug- Preclinical study of honokiol intravenous freeze-drying liposomes”, Project Leader.

2.       National science and technology major project “Research on the quality control of Traditional Chinese medicine and construction of information platform-research on the quality control of Aurantii Fructus” , Project Leader of the subtopic.

3.       The National 973 Project "Research on the inheritance and innovation of the theory of Chinese herbal property-study on the properties of genuine medicinal materials”, one of the lead researchers.

4.       Revision of quality standard of traditional Chinese medicines in China Pharmacopeia 2010. -research on the quality control of Flos Inulae Japonicae  Project Leader of the subtopic.

5.       Science and technology major project of State Administration of Traditional Chinese Medicine “Research on a traditional Chinese medicine Echinacea purpurea and its new preparation”, Award Beijing Science and Technology Advancement Award (Third Class), third awardee.

6.       National “Tenth Five Year Plan” project “Study on the Preparation Standards of Traditional Chinese Medicine Rhizoma Atractylodis Macrocephalae”, Project Leader of the subtopic.

7.       National “ninth Five Year Plan” project “Research on the quality standards and reference substance of 66 common used Traditional Chinese Medicine-special subject of Radix Rubiae”, Award Beijing Science and Technology Advancement Award (Second Class), first awardee.

8.       National “Eitghth Five Year Plan” project “Research on the quality standards and reference substance of common used Traditional Chinese Medicine-special subject of Manchurian Wildginger”, Award State Administration of Traditional Chinese Medicine Science and Technology Advancement Award (First Class), second awardee, 1996.

9.       National “Eitghth Five Year Plan” project “Research on the quality standards and reference substance of common used Traditional Chinese Medicine-special subject of Veratrum nigrum L.”, Award State Administration of Traditional Chinese Medicine Science and Technology Advancement Award (First Class), first awardee, 1996.

10.   International cooperative project “Research on the HPLC fingerprints of the Traditional Chinese Medicines in China Pharmacopeia 2010”, Project Leader.

11.   International cooperative project “The establishment of traditional Chinese medicine fingerprint rapid analysis platform based on LC-MS and online activity detection techniques. ”, Project Leader.

Professor Chen has developed several new drugs, published more than 50 papers, applied and obtained four patents, published and edited 5 monographs, and has trained more than 20 graduate students.

HONORS

1.       Award Beijing Science and Technology Advancement Award (Third Class) for “ Study on the Echinacea Purpurea as a new kind of Medicinal Materials and its New-Drug Preparation”, China, 2004

2.       Award the State Technological Invention (Second Class) for “ Study on Quality Standard and reference substance of 66 Traditional Chinese Medicines”, China, 2001

3.       Prominent Teacher of Peking University Health Science Center.

SELECTED PUBLICATIONS

 

1.  Guoqiang Liua, Jing Dong, Hong Wang, Yuki Hashi, Shizhong Chen？. Characterization of alkaloids in Sophora flavescens Ait. by high-performance liquid chromatography–electrospray ionization tandem mass spectrometry Journal of Pharmaceutical and Biomedical Analysis 2011,54 :1065-1072

2.  Guo-Qang Liu，Jing Dong, Hong Wang, Yuki Hashi Shi-Zhong Chen？. Differentiation of four pairs of furocoumarin isomers by electrospray ionization tandem mass spectrometry Eur. J. mass spectrom. 2010,16:215-220

3. Guoqiang Liu, Jing Dong, Hong Wang, Leren Wan, Yuki Hashi, Shizhong Chen？. ESI Fragmentation Studies of Four Tea Catechins. Chemical Journal of Chinese Universities. 2009, 30(8):1566~1570

4.  Hui Li，Leren Wan，Yuki Hashi ，Shizhong Chen*. Fragmentation study of a 8-C-glycosyl isoflavone, puerarin, using electrospray ion trap time-of-flight mass spectrometry at high resolution.  Rapid Commun. Mass Spectrom. 2007,21: 2497–2504

5.  Die Hu, Xiaoyan Liu, Yinye Wang, Shizhong Chen*. Cyclovirobuxine D ameliorates acute myocardial ischemia by KATP channel opening, nitric oxide release and anti-thrombosis. Eur J Pharmacol 2007,569: 103–109

6.  Shujuan Liu, Zongtao Lin, Hong Wang, Shizhong Chen*. Quantification of eugenol and bancroftione in Caryophylli Fructus using high-performance liquid chromatography. Journal of Chinese Pharmaceutical Sciences. 2010, 6: 459-463.

7.  Ying Xu, Jing Dong, Hong Wang, Leren Wan, Yuki Hashi, Shizhong Chen*. Fragmentation Study of the C Ring in Flavone and Isoflavone Aglycones by Electrospray Ion Trap Time-of-Flight Mass Spedtrometry. Chemical Journal of Chinese Universities. 2009, 30(1):46-50.

8. Shuijuan Liu, Shiheng Luo, Hong Wang, Shizhong Chen*. UFLC determination of eugenol and 2-hydroxy-4,6-dimethoxy-5-methylacetophenone in Eugenia caryophyllata Thunb. Chinese Journal of Pharmaceutical Analysis. 2011, 31(1):161-161

9. Guoqiang Liu, Jing Dong, Hong Wang, Leren Wan, Yuki Hashi, Shizhong Chen*. ESI Fragmentation Studies of Four Tea Catechins. Chemical Journal of Chinese Universities. 2009, 30(8):1566-1570

10. Weixin Zeng, Hong Wang, Lulu Sun, Guanxun Zhao, Shizhong Chen*, Determination of α-pinene,β-pinene,limonen,and 1,8-cineole in Flos Magnoliaevolatile oil soft capsula by capillary gas chromatography. Chinese Traditional and Herbal Drugs. 2009,40(8):1232-1235

11．Guoqiang Liu, Jing Dong, Hong Wang, Leren Wan, Yuki Hashi, Shizhong Chen*. The Fragmentation Study of EGC/GC and EGCG/GCG Using ESI-IT-TOF. Journal of Chinese Mass Spectrometry Society. 2009,30(5): 287-294

12.  Hui Li, Leren Wan, Hong Wang, Hashi Yuki, Shizhong Chen*. Identification and Mass Spectrometric Characterization of Isomeric Isoflavone Aglycones by ESI-IT-TOF Mass Spectrometry. Chemical Journal of Chinese Universities. 2007,28(12):2284-2289

13．Liangliang Yin, Zichen Liu, Hui Li, Shizhong Chen*. Analysis of the content of effective components in Cinnamomum cassia Presl and Cinnamomi Ramulus. Chinese Traditional and Herbal Drugs. 2007,38(7):109-415

14.  Zhanliang Wang, Hong Wang, Shizhong Chen*. Analysis of Ginsenosides in Sheng-Mai-Yin Decoction by High Performance Liquid Chromatography-Diode Array Detection-Electrospray Mass Spectrometry.  Chinese Journal of Chromatography. 2006,

24（4）: 325-330.

15. Shizhong Chen, Hui Jia, Yaohua Wu, Hong Wang. Pharmacokinetics of honokiol in rats. Journal of Peking University (Health Sciences). 2004,（36）:76～78

16 .Xiaoxue Zhang, Shizhong Chen, Yinye Wang*. Honokiol up-regulates prostacyclin syntheaseprotein expression and inhibits endothelial cell apoptosis European. J. Pharmacol ,2007,554:1-7