姜勇教授,博士生导师
国家自然科学基金优秀青年基金获得者
教育部新世纪优秀人才基金获得者
研究领域:
(1)中药药效物质基础及作用机制研究
(2)基于药效物质的中药整体质量控制新技术及其应用
电话&传真: 010-82802719
联系邮箱: yongjiang@bjmu.edu.cn
个人简介
2003年于北京大学获得博士学位;2008-2010在法国皮尔法伯研究所从事博士后研究。现为北京大学药学院新体制长聘教授,博士生导师,天然药物学系主任。国家“万人计划”科技创新领军人才、国家自然科学基金优秀青年基金获得者、教育部新世纪优秀人才,国家重点研发项目首席专家。
北京大学药学院新体制长聘教授,博士生导师,天然药物学系主任。国家“万人计划”科技创新领军人才、国家自然科学基金优秀青年基金获得者、教育部新世纪优秀人才,国家重点研发项目首席专家。兼任中国野生植物保护协会肉苁蓉保育委员秘书长、中国仪器仪表学会药物质量分析与过程控制分会常务理事,北京药学会药物分析专委会副主任委员,世中联中药分析专业委员会理事,中国医疗保健国际交流促进会中药学分会委员等,为多个国内外知名杂志,如Acta Pharm Sin B、Pharmacol Res、Chem & Biodiv、药学学报、中国中药杂志等编委。
主要研究成果
长期致力于“中药药效物质及其作用机制研究”、“中药的质量控制与评价”,共发表论文300余篇,其中以第一和通讯作者在Adv Sci, Med Res Rev, Lab on Chip, Org Lett, Anal Chem, J Nat Prod等国际权威杂志发表SCI论文100余篇,授权发明专利32项。先后主持国家重点研发项目、国家重大新药创制专项、国家自然科学基金、国家中药标准化等项目,作为主要完成人获得国家科技进步二等奖1项及省部级科技奖励9项。获得新药证书 4个,临床批件2个;建立的20余项标准被《中国药典》及国家药品标准收载。
研究领域
(1)天然药物活性成分与创新药物研究
(2)中药质量控制与评价
(3)中药多组学研究
代表性论文
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Ningning Wei#, Haining Lv#, Yang Wu, Shilong Yang, Xiaoying Sun, Ren Lai, Yong,Jiang*, Kewei Wang*. Selective activation of nociceptor TRPV1 channel and reversal of inflammatory pain in mice by a novel coumarin derivative muralatin L fromMurraya alata. Journal of Biological Chemistry, 2016, 291, 640-651.
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Chen Zhang, Shu Wang, Kewu Zeng, Jun Li, Daneel Ferreira, Jordan K Zjawiony, Bingyu Liu, Xiaoyu Guo, Hongwei Jin, Yong Jiang*, Pengfei Tu*. Nitric oxide inhibitory dimeric sesquiterpenoids from Artemisia rupestris. Journal of Natural Products, 2016, 79, 213-223.
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Bingyu Liu, Chen Zhang, Kewu Zeng, Jun Li, Xiaoyu Guo, Mingbo Zhao, Pengfei Tu, Yong Jiang*. Organic Letters, 2015, 17, 4380-4383.
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Haining Lv, Ran Wen, Ying Zhou, Kewu Zeng, Jun Li, Xiaoyu Guo, Pengfei Tu, Yong Jiang*. Nitrogen oxide inhibitory trimeric and dimeric carbazole alkaloids from Murraya tetramera. Journal of Natural Product, 2015, 78, 2432-2439.
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Haining Lv, Shu Wang, Kewu Zeng, Jun Li, Xiaoyu Guo, Daneel Ferreira, Jordan K. Zjawiony, Pengfei Tu, Yong Jiang*. Anti-inflammatory coumarin and benzocoumarin derivatives from Murraya alata. Journal of Natural Product, 2015, 78, 279–285.
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Wenguang Wang, Xiaoli Ma, Xiaoyu Guo, Mingbo Zhao, Pengfei Tu, Yong Jiang*. A series of strategies for solving the shortage of reference standardsfor multi-components determination of traditional Chinese medicine, Mahoniae Caulis as a case. Journal of Chromatography A, 2015, 1412, 100–111.
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Yuelin Song, Na Zhang, Shepo Shi, Jun Li, Qian Zhang, Yunfang Zhao, Yong Jiang*, Pengfei Tu*. Large-scale qualitative and quantitative characterization ofcomponents in Shenfu injection by integrating hydrophilic interactionchromatography, reversed phase liquid chromatography, and tandemmass spectrometry. Journal of Chromatography A, 2015, 1407, 106–118.
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Yuelin Song, Na Zhang, Shepo Shi, Jun Li, Yunfang Zhao, Qian Zhang, Yong Jiang*, Pengfei Tu*.Homolog-focused profiling of ginsenosides based on the integrationof step-wise formate anion-to-deprotonated ion transition screeningand scheduled multiple reaction monitoring. Journal of Chromatography A, 2015, 1406, 136–144.
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Kewu Zeng, Qian Yu, Lixi Liao, Fangjiao Song, Haining Lv, Yong Jiang*, Pengfei Tu*. Anti-neuroinflammatory effect of MC13, a novel coumarin compound from condiment Murraya, through inhibiting lipopolysaccharide-induced TRAF6-TAK1-NF-κB, P38/ERK MAPKS and Jak2-Stat1/Stat3 pathways. Journal of Cellular Biochemistry, 2015, 116, 1286–1299.
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Jinfeng Chen, Yuelin Song, Xiaoyu Guo, Pengfei Tu, Yong Jiang*. Characterization of the herb-derived components in rats following oral administration of Carthamus tinctorius extract by extracting diagnostic fragment ions (DFIs) in the MSn chromatograms. Analyst, 2014, 139, 6474–6485.
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Yong Jiang*, Kewu Zeng, Bruno David, Georges Massiot. Constituents of Vigna angularis and their in vitro anti-inflammatory activity. Phytochemistry, 2014, 107, 111–118.
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Ablajan Turak, Shepo Shi, Yong Jiang*, Pengfei Tu*. Dimeric guaianolides from Artemisia absinthium. Phytochemistry, 2014, 105, 109–114.
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Shu Wang, Jian Sun, Kewu Zeng, Xiaoguang Chen, Wanqi Zhou, Chen Zhang, Hongwei Jin, Yong Jiang*, Pengfei Tu*. Sesquiterpenes from Artemisia argyi: Absolute Configuration and Biological Activities. European Journal of Organic Chemistry, 2014, 5, 973–983.
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Wei Lei, Yuelin Song, Xiaoyu Guo, Pengfei Tu, Yong Jiang*. Habitat differentiation and degradation characterization of Cinnamomi Cortex by 1H NMR spectroscopy coupled with multivariate statistical analysis. Food Research International, 2015, 67, 155–162.
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Yong Jiang*, Bruno David, Pengfei Tu, Yves Barbin.Recent analytical approaches in quality control of traditional Chinese medicines-A review. Analytica Chimica Acta, 2010, 657, 9–18.
省部级以上科技成果奖
1. 基于活性成分中药质量控制新技术及在药材和红花注射液等中的应用,2015年度国家科技进步二等奖,第二完成人.
2. 基于活性成分的中药质量控制创新体系及其应用,2011年度教育部高等学校优秀科技成果奖科技进步奖二等奖,第二完成人.
3. 远志属化学成分、生物活性、质量控制及体内代谢研究,2010年度教育部高等学校优秀科技成果自然科学二等奖,第二完成人.
4. 新疆特种植物肉苁蓉有效成分对脑保护作用机制的研究,2010年度新疆生产建设兵团科学技术进步奖二等奖,第十完成人.
5. 中药肉苁蓉的栽培、加工技术研究与应用,2008年度教育部高等学校优秀科技成果奖科技进步奖一等奖, 第九完成人.
6. 威灵仙等5种常用中药化学成分和质量标准示范性研究,2007年度中华中医药学会李时珍医药创新奖,第三完成人.
7. 劲酒指纹图谱研究,2007年度湖北省科技进步奖三等奖,第六完成人.
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